导师类型：博士生导师
单 位：05中药研究所
出生年月：1985年01月
专业职务：研究员
学 位：理学博士
毕业学校：新加坡国立大学
第一学科：中药学
第二学科：中药学
研究方向：药理学，中药药理，化学生物学，药物化学，有机合成，生物材料，蛋白组学
联系电话：18260046833
邮 箱：jgwang@icmm.ac.cn
邮 编：100700
联系地址：东直门内南小街16号 中药所
个人简介：王继刚，中国中医科学院中药研究所、青蒿素研究中心研究员，博士生导师。主要研究青蒿素抗疟、抗癌的机制，以及其他中药及天然产物的药物靶标与作用机理。团队结合[b]化学生物学、蛋白质组学（生物质谱）、代谢组学以及分子生物学[/b]等相关交叉领域的研究方法、围绕中药有效成分的作用靶点及其作用机制展开系统研究。近年来在包括青蒿素在内的中药及天然产物的靶标、作用机理和抗药研究及细胞自噬药物筛选平台建立等方面取得了一系列研究进展与突破，近年已发表SCI论文110余篇，[size=100]以通讯/第一作者在 IF>10 的期刊发表论文60 余篇，包括 [/size][i]The New England Journal of Medicine、Lancet、Lancet Infectious Disease、Nature Communications、Nature Protocols、JACS、Angew. Chem. Intl. Ed.、[/i][i]ACS Central Science[/i][i]、[/i][i]Autophagy[/i][i]、[/i][i]Trends in Pharmacological Sciences[/i][i]、[/i][i]Pharmacology & Therapeutics[/i][i]、Medicinal Research Reviews、[/i][color=#222222][i]Journal of Extracellular Vesicles[/i][/color][i]、[/i][i]Theranostics[/i][i]、[/i][i]Redox Biology[/i][i]、[/i][i]Molecular & Cellular Proteomics [/i]等国际高水平学术期刊。其中青蒿素抗疟机理的研究文章被Faculty of 1000收录并推荐为教科书式的参考及阅读文献。撰写Methods Enzymol.书籍章节2篇。近年来主持科技部重大专项新药创制子项目，国自然面上项目，[size=100]国家重点研发计划合成生物学重点专项，国家中医药管理局“中医药传承创新团队”，[/size]同时兼职多种国际权威刊物的编委或审稿人；昆药集团青蒿素重点实验室科学顾问。
论文：
Extracellular Vesicles in Type 2 Diabetes Mellitus：Key Roles in Pathogenesis, Complication, and Therapy Journal of Extracellular Vesicles (IF: 11) 2019/5/26
A Temporizing Solution to “Artemisinin Resistance” The New England Journal of Medicine （IF：79.2） 2019/5/1
Development of GLUT1-targeting alkyl glucosidemodified dihydroartemisinin liposomes for cancer therapy Nanoscale (IF: 7.3) 2020/11/5
Artesunate-induced mitophagy alters cellular redox status Redox biology（IF：9.9） 2018/9/12
Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression Theranostics（IF：9.02） 2018/7/19
ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction Clinical and Translational Medicine (IF: 7.9) 2020/10/1
Artemisinin as an Anti-Cancer Drug: Recent Advances in Target Profiling and Mechanisms of Action Medicinal Research Reviews（IF：9.2） 2017/9/19
Advances in the research on the targets of anti-malaria actions of artemisinin Pharmacology & Therapeutics (IF: 11.4) 2020/12/1
Development of a novel method for quantification of autophagic protein degradation by AHA labeling Autophagy（IF：11.75） 2014/9/18
The potential of artemisinins as anti-obesity agents via modulating the immune system Pharmacology & Therapeutics (IF: 11.4) 2020/12/1
Recent Advances in Quantitative and Chemical Protoemics for Autophagy Studies Autophagy（IF：11.75） 2017/10/19
Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors Autophagy （IF：11.75） 2018/9/12
Near-infrared-II nanoparticles for cancer imaging of immune checkpoint programmed death-ligand 1 and photodynamic/immune therapy ACS nano (IF: 14.6) 2021/2/16
Target identification of natural and traditional medicines with quantitative chemical proteomics approaches Pharmacology & Theraputics （IF：11.12） 2016/7/13
Quantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy Autophagy （IF：11.1） 2016/8/17
The analgesic and antidepressant properties of dihydroartemisinine in the neuropathic pain mice: By the downregulation of HnRNPA1 in the spinal cord and hippocampus Clinical and Translational Medicine (IF: 8.55) 2022/2/1
Triple artemisinin-based combination therapies for malaria: proceed with caution The Lancet（IF: 60.4） 2020/12/19
Mechanism-Guided Design and Synthesis of Mitochondria- targeting Artemisinin Analog with Enhanced Anticancer Activity Angew. Chem. Int. Ed.（IF：12.1） 2016/9/21
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease International Journal of Biological Sciences (IF: 10.75) 2022/1/1
Unpacking “Artemisinin Resistance” Trends in Pharmacological Sciences (IF:12.8) 2017/7/18
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA Military midical research (IF: 34.91) 2022/6/1
Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labelling Nature Protocols (IF:12.4) 2017/1/24
Deciphering the Effects and Mechanisms of Yi-Fei-San-Jie-pill on Non-Small Cell Lung Cancer With Integrating Network Target Analysis and Experimental Validation Frontiers in Pharmacology (IF: 5.98) 2022/5/1
Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anti-colorectal Cancer Activity ACS Central Sciences (IF:11.2) 2018/7/24
Discovery and repurposing of artemisinin Frontiers of Medicine (IF: 9.92) 2022/3/1
Haem-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum Nature Communications (IF:12.4) 2015/12/18
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics International Journal of Biological Sciences (IF: 10.75) 2022/2/1
Celastrol inhibits inflammation via targeting PKM2-dependent Warburg effect Military Medical Research （IF: 34.91） 2022/5/1
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1 Acta Pharmaceutica Sinica B (IF: 14.90) 2022/5/1
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets Aging and Disease （IF: 9.96） 2022/6/1
Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT Frontiers in Pharmacology (IF: 5.98) 2021/3/1
Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy Nanoscale (IF: 8.30) 2021/8/1
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion Journal of Neuroinflammation (IF: 9.58) 2021/8/1
Thiophene donor for NIR-II fluorescence imaging guided photothermal/photodynamic/chemo combination therapy Acta Biomaterialia (IF: 10.63) 2021/6/1
Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model Clinical and Translational Medicine (IF: 8.55) 2021/6/1
Recent pharmacological advances in the repurposing of artemisinin drugs Medicinal Research Reviews (IF: 12.38) 2021/6/1
Study towards improving artemisinin-based combination therapies Natural Product Reports （IF: 15.11） 2021/7/2
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity Therapeutic Advances in Medical Oncology (IF: 6.852) 2020/7/13
Artesunate synergizes with sorafenib to induce ferroptosis inhepatocellular carcinoma Acta Pharmacologica Sinica (IF: 5.064) 2020/7/22
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification Signal Transduction and Targeted Therapy (IF: 13.493) 2020/5/21
Exosomes as potential sources of biomarkers in colorectal cancer Cancer Letters (IF: 7.36) 2020/4/28
Skeletal meroterpenoids from Ganoderma petchii mushrooms that potentially stimulate umbilical cord mesenchymal stem cells Bioorganic Chemistry (IF: 4.831) 2020/4/1
Malaria eradication The Lancet (IF: 60.392) 2020/4/25
Preparedness is essential for malaria-endemic regions during the COVID-19 outbreak The Lancet (IF: 60.392) 2020/4/4
2H-Azirine-based Reagents for Chemoselective Bioconjugation at Carboxyl Residues inside Live Cells Journal of the American Chemical Society (IF: 14.612) 2020/4/1
Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation Journal of the American Chemical Society (IF: 14.612) 2019/11/20
Suboptimal dosing triggers artemisinin partner drug resistance Lancet Infectious Disease (IF: 24.446) 2019/11/1
Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives Medicinal Research Reviews (IF: 9.3) 2019/11/1
Artemisinin-(Iso)quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria Angewandte Chemie International Edition (IF: 12.959) 2019/9/9
Re: A Temporising Solution to "Artemisinin Resistance", Reply New England Journal of Medicine (IF: 74.699) 2019/9/5
专著：
Target Profiling of an Anticancer Drug Curcumin by an in situ Chemical Proteomics Approach, Methods in Molecular Biology Humana, New York, NY
Proteomic profiling of de novo protein synthesis in starvation-induced autophagy using bio-orthogonal noncanonical amino acid tagging. Elsevier（Methods Enzymol.）
Drug Target Identification using an iTRAQ-Based Quantitative Chemical Proteomics Approach. Elsevier （Methods Enzymol.）
获奖：
Extracellular Vesicles in Type 2 Diabetes Mellitus：Key Roles in Pathogenesis, Complication, and Therapy Journal of Extracellular Vesicles (IF: 11)
A Temporizing Solution to “Artemisinin Resistance” The New England Journal of Medicine （IF：79.2）
Development of GLUT1-targeting alkyl glucosidemodified dihydroartemisinin liposomes for cancer therapy Nanoscale (IF: 7.3)
Artesunate-induced mitophagy alters cellular redox status Redox biology（IF：9.9）
Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression Theranostics（IF：9.02）
ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction Clinical and Translational Medicine (IF: 7.9)
Artemisinin as an Anti-Cancer Drug: Recent Advances in Target Profiling and Mechanisms of Action Medicinal Research Reviews（IF：9.2）
Advances in the research on the targets of anti-malaria actions of artemisinin Pharmacology & Therapeutics (IF: 11.4)
Development of a novel method for quantification of autophagic protein degradation by AHA labeling Autophagy（IF：11.75）
The potential of artemisinins as anti-obesity agents via modulating the immune system Pharmacology & Therapeutics (IF: 11.4)
Recent Advances in Quantitative and Chemical Protoemics for Autophagy Studies Autophagy（IF：11.75）
Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors Autophagy （IF：11.75）
Near-infrared-II nanoparticles for cancer imaging of immune checkpoint programmed death-ligand 1 and photodynamic/immune therapy ACS nano (IF: 14.6)
Target identification of natural and traditional medicines with quantitative chemical proteomics approaches Pharmacology & Theraputics （IF：11.12）
Quantitative Chemical Proteomics Profiling of de novo Proteins Synthesis during Starvation-Mediated Autophagy Autophagy （IF：11.1）
The analgesic and antidepressant properties of dihydroartemisinine in the neuropathic pain mice: By the downregulation of HnRNPA1 in the spinal cord and hippocampus Clinical and Translational Medicine (IF: 8.55)
Triple artemisinin-based combination therapies for malaria: proceed with caution The Lancet（IF: 60.4）
Mechanism-Guided Design and Synthesis of Mitochondria- targeting Artemisinin Analog with Enhanced Anticancer Activity Angew. Chem. Int. Ed.（IF：12.1）
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease International Journal of Biological Sciences (IF: 10.75)
Unpacking “Artemisinin Resistance” Trends in Pharmacological Sciences (IF:12.8)
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA Military midical research (IF: 34.91)
Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labelling Nature Protocols (IF:12.4)
Deciphering the Effects and Mechanisms of Yi-Fei-San-Jie-pill on Non-Small Cell Lung Cancer With Integrating Network Target Analysis and Experimental Validation Frontiers in Pharmacology (IF: 5.98)
Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anti-colorectal Cancer Activity ACS Central Sciences (IF:11.2)
Discovery and repurposing of artemisinin Frontiers of Medicine (IF: 9.92)
Haem-activated Promiscuous Targeting of Artemisinin in Plasmodium falciparum Nature Communications (IF:12.4)
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics International Journal of Biological Sciences (IF: 10.75)
Celastrol inhibits inflammation via targeting PKM2-dependent Warburg effect Military Medical Research （IF: 34.91）
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1 Acta Pharmaceutica Sinica B (IF: 14.90)
Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets Aging and Disease （IF: 9.96）
Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT Frontiers in Pharmacology (IF: 5.98)
Hemin-lipid assembly as an artemisinin oral delivery system for enhanced cancer chemotherapy and immunotherapy Nanoscale (IF: 8.30)
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion Journal of Neuroinflammation (IF: 9.58)
Thiophene donor for NIR-II fluorescence imaging guided photothermal/photodynamic/chemo combination therapy Acta Biomaterialia (IF: 10.63)
Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model Clinical and Translational Medicine (IF: 8.55)
Recent pharmacological advances in the repurposing of artemisinin drugs Medicinal Research Reviews (IF: 12.38)
Study towards improving artemisinin-based combination therapies Natural Product Reports （IF: 15.11）
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity Therapeutic Advances in Medical Oncology (IF: 6.852)
Artesunate synergizes with sorafenib to induce ferroptosis inhepatocellular carcinoma Acta Pharmacologica Sinica (IF: 5.064)
Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification Signal Transduction and Targeted Therapy (IF: 13.493)
Exosomes as potential sources of biomarkers in colorectal cancer Cancer Letters (IF: 7.36)
Skeletal meroterpenoids from Ganoderma petchii mushrooms that potentially stimulate umbilical cord mesenchymal stem cells Bioorganic Chemistry (IF: 4.831)
Malaria eradication The Lancet (IF: 60.392)
Preparedness is essential for malaria-endemic regions during the COVID-19 outbreak The Lancet (IF: 60.392)
2H-Azirine-based Reagents for Chemoselective Bioconjugation at Carboxyl Residues inside Live Cells Journal of the American Chemical Society (IF: 14.612)
Chemical Probes Reveal Sirt2’s New Function as a Robust “Eraser” of Lysine Lipoylation Journal of the American Chemical Society (IF: 14.612)
Suboptimal dosing triggers artemisinin partner drug resistance Lancet Infectious Disease (IF: 24.446)
Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives Medicinal Research Reviews (IF: 9.3)
Artemisinin-(Iso)quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria Angewandte Chemie International Edition (IF: 12.959)
Re: A Temporising Solution to "Artemisinin Resistance", Reply New England Journal of Medicine (IF: 74.699)
