导师类型：博士生导师
单 位：06针灸研究所
出生年月：1975年12月
专业职务：研究员
学 位：医学博士
毕业学校：中国中医科学院
第一学科：中西医结合
第二学科：中西医结合基础
研究方向：针灸作用的神经机制研究
联系电话：64089420
邮 箱：
邮 编：100700
联系地址：北京市东城区东直门内南小街16号 中国中医科学院针灸研究所
个人简介：高昕妍，博士，研究员，博士生导师。针灸研究所机能研究室主任、学科发展办公室主任。2005年毕业于中国中医科学院，获中西医结合博士学位。香港浸会大学博士后，约翰霍普金斯大学医学院访问学者。担任《中国疼痛医学杂志》、《针刺研究》编委，担任中国针灸学会学科与学术工作委员会副主任委员兼秘书长、北京市生理科学会常务理事。从事针灸作用机制研究，研究领域包括针灸使动因素，穴位动态变化及功能，针灸的传入信息编码，针灸治疗内脏疾病的效应规律与机制等。以往主持研究获得中国针灸学会科学技术一等、中国中医科学院[color=#222222]科学技术一等奖等共[/color]7项[color=#222222]。[/color]主持科技部和自然基金课题十余项。共发表文章70余篇，含疼痛和神经科学领域专业性期刊。
论文：
Acupuncture-like stimulation at auricular point Heart evokes cardiovascular inhibition via activating the cardiac-related neurons in the Nucleus TractusSolitarius. Brain Res 2011/4/22
NMDA receptor-dependent synaptic activity in dorsal motor nucleus of vagus mediates the enhancement of gastric motility by stimulating ST36. Evid Based Complement Alternat Med. 2012/6/14
Neurons in the nucleus tractus solitarius mediate the acupuncture analgesia in visceral pain rats. Auton Neurosci. 2014/8/4
Acupuncture at heterotopic acupoints enhances jejunal motility in constipated and diarrhoeic rats. World J Gastroenterol 2014/12/28
Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats. BMC Complement Altern Med. 2015/8/8
Acupuncture at heterotopic acupoints facilitates distal colonic motility via activating M3 receptors and somatic afferent C-fibers in normal, constipated, or diarrhoeic rats. Neurogastroenterol Motil. 2015/10/13
β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints. PLoS One 2016/12/15
Cutaneous Hypersensitivity as an Indicator of Viscera Inflammation via C-Nociceptor’s Axon Bifurcation Neurosci Bull 2021/1/1
Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia J Pain Res 2017/10/1
Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity Pain 2021/4/1
Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats J Pain Res 2018/11/1
Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury Pain 2019/12/1
Signaling Interaction between Facial and Meningeal Inputs of the Trigeminal System Mediates Peripheral Neurostimulation Analgesia in a Rat Model of Migraine Neuroscience 2020/5/1
Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial. Front. Neurol 2022/7/7
Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia Neurosci Bull 2022/4/26
专著：
针刺镇痛的节段性机制与全身性机制 中国针灸学会科技进步奖
针刺不同穴位对内脏感觉-运动的调控机制和规律研究 中国针灸学会科技进步奖
耳针激活耳迷走神经调节内脏功能的效应及机制研究 中国中西医结合学会科技进步奖
耳针激活耳-迷走神经调节内脏功能的效应及机制研究 中国中医科学院科技进步奖
穴位-靶器官联系的节段性和全身性机制 中国针灸学会科技进步奖
获奖：
Acupuncture-like stimulation at auricular point Heart evokes cardiovascular inhibition via activating the cardiac-related neurons in the Nucleus TractusSolitarius. Brain Res
NMDA receptor-dependent synaptic activity in dorsal motor nucleus of vagus mediates the enhancement of gastric motility by stimulating ST36. Evid Based Complement Alternat Med.
Neurons in the nucleus tractus solitarius mediate the acupuncture analgesia in visceral pain rats. Auton Neurosci.
Acupuncture at heterotopic acupoints enhances jejunal motility in constipated and diarrhoeic rats. World J Gastroenterol
Acupuncture at homotopic acupoints exerts dual effects on bladder motility in anesthetized rats. BMC Complement Altern Med.
Acupuncture at heterotopic acupoints facilitates distal colonic motility via activating M3 receptors and somatic afferent C-fibers in normal, constipated, or diarrhoeic rats. Neurogastroenterol Motil.
β1/2 or M2/3 Receptors Are Required for Different Gastrointestinal Motility Responses Induced by Acupuncture at Heterotopic or Homotopic Acupoints. PLoS One
Cutaneous Hypersensitivity as an Indicator of Viscera Inflammation via C-Nociceptor’s Axon Bifurcation Neurosci Bull
Application of the chronic constriction injury of the partial sciatic nerve model to assess acupuncture analgesia J Pain Res
Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity Pain
Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats J Pain Res
Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury Pain
Signaling Interaction between Facial and Meningeal Inputs of the Trigeminal System Mediates Peripheral Neurostimulation Analgesia in a Rat Model of Migraine Neuroscience
Caffeine Attenuates Electroacupuncture Effect on Pressure Pain Threshold and Tolerance in Healthy Individuals: A Randomized Controlled Trial. Front. Neurol
Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia Neurosci Bull
