导师类型：博士生导师
单 位：07中医基础理论研究所
出生年月：1979年01月
专业职务：研究员
学 位：医学博士
毕业学校：瑞士日内瓦大学
第一学科：中西医结合
第二学科：中西医结合基础
研究方向：纳米中药在代谢性疾病防治中的应用研究；中医药防治病毒性疾病基础研究
联系电话：18710047723
邮 箱：18710047723@163.com
邮 编：100700
联系地址：北京市东城区东直门内南小街16号
个人简介：李宁，女，研究员。2009年毕业于瑞士日内瓦大医学院细胞生理与代谢系，获得医学博士学位，其后在瑞士日内瓦大医学院进行博士后研究工作，主要研究方向是线粒体在代谢性疾病中的病理生理学基础。2013年至2017年于中国医学科学院基础医学研究所生物化学与分子生物学系任副研究员，从事病毒致病机制与干预研究，同期获得英国伦敦大学clinical trials第二硕士学位。自2017年，任职于中国中医科学院中医基础理论研究所-生物医学工程技术中心，从事纳米中药在代谢性疾病防治中的应用及中医药防治病毒性疾病基础研究。曾两次获得欧洲糖尿病研究基金（EFSD）资助，归国后主持或参与国家自然科学基金、“973”计划、国家重点研发战略性国际科技创新合作重点专项等项目。作为主要完成者研究成果发表在[i]Nano Today[/i]，[i]Diabetes[/i]，[i]Trends Endocrinal Metab[/i]., [i]Redox Biology[/i]等国际权威杂志，参与撰写论著2部。
论文：
Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Promoted Wound Healing by Utilizing Coaxial PCL/Gelatin Nanofiber Membrane International Journal of Molecular Sciences 2022/2/1
Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis Frontiers in Bioengineering and Biotechnology 2022/1/15
Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins Biochem Cell Biol 2007/7/1
Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury Biochem Cell Biol 2007/7/1
The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress Biochem Soc Trans 2008/4/1
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction J Biol Chem 2009/5/1
Glucose metabolism in breast cancer and its implication in cancer therapy Int J Clin Med 2011/2/1
Mitochondrial dysfunction in pancreatic β-cells Trends Endocrinol Metab 2012/6/1
Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining Front Pharmol. 2021/5/31
NAD(P)H oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Diabetes 2012/6/1
Mitochondrial hormesis in pancreatic β-cells: does uncoupling protein 2 play a role? Oxid Med Cell Longev 2012/11/1
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids PloS One 2014/8/1
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections Nat Commun 2014/5/1
牛磺熊去氧胆酸减轻TGF-β1诱导的MRC-5纤维化表型 基础医学与临床 2015/5/1
Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse Sci China Life Sci 2015/3/1
Neuraminidase of influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture J Virol 2015/4/1
Diabetogenic millieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets Hum Mol Genet 2015/4/1
FAT10 is critical in influenza A virus replication by inhibiting type I IFN J Immunol 2016/6/1
Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity Redox Biology 2017/10/1
MicroRNAs from plants to animals, do they define a new messenger for communication? Nutrition & Metabolism 2018/10/1
Tauroursodeoxycholic Acid (TUDCA) Inhibits Influenza A Viral Infection by Disrupting Viral Proton Channel M2 Science Bulletin 2019/1/1
Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System Frontiers in Bioengineering and Biotechnology 2020/8/1
Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability Frontiers in Chemistry 2020/10/1
Peptide-based high-density lipoprotein promotes adipose tissue browning and restrains development of atherosclerosis and type 2 diabetes Nano Today 2021/2/1
专著：
Frontiers in Biomaterials, chapter 7: Stem cell-based modalities: from basic biology to integration and regeneration. Frontiers in Biomaterials
中医药防治糖尿病胰岛素抵抗技术平台建立与应用 其他
获奖：
Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Promoted Wound Healing by Utilizing Coaxial PCL/Gelatin Nanofiber Membrane International Journal of Molecular Sciences
Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis Frontiers in Bioengineering and Biotechnology
Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins Biochem Cell Biol
Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury Biochem Cell Biol
The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress Biochem Soc Trans
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction J Biol Chem
Glucose metabolism in breast cancer and its implication in cancer therapy Int J Clin Med
Mitochondrial dysfunction in pancreatic β-cells Trends Endocrinol Metab
Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining Front Pharmol.
NAD(P)H oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Diabetes
Mitochondrial hormesis in pancreatic β-cells: does uncoupling protein 2 play a role? Oxid Med Cell Longev
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids PloS One
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections Nat Commun
牛磺熊去氧胆酸减轻TGF-β1诱导的MRC-5纤维化表型 基础医学与临床
Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse Sci China Life Sci
Neuraminidase of influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture J Virol
Diabetogenic millieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets Hum Mol Genet
FAT10 is critical in influenza A virus replication by inhibiting type I IFN J Immunol
Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity Redox Biology
MicroRNAs from plants to animals, do they define a new messenger for communication? Nutrition & Metabolism
Tauroursodeoxycholic Acid (TUDCA) Inhibits Influenza A Viral Infection by Disrupting Viral Proton Channel M2 Science Bulletin
Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System Frontiers in Bioengineering and Biotechnology
Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability Frontiers in Chemistry
Peptide-based high-density lipoprotein promotes adipose tissue browning and restrains development of atherosclerosis and type 2 diabetes Nano Today
