导师类型：博士生导师
单 位：07中医基础理论研究所
出生年月：1981年07月
专业职务：副研究员
学 位：理学博士
毕业学校：丹麦哥本哈根大学
第一学科：中西医结合
第二学科：中西医结合基础
研究方向：中医药生物工程和再生医学；中医药病毒防治基础研究
联系电话：13269038255
邮 箱：ruodanxu@gmail.com
邮 编：100700
联系地址：东直门内南小街16号
个人简介：2010年12月获丹麦哥本哈根大学博士，相继在瑞士日内瓦大学和德国科隆大学从事博士后研究，随后任职于丹麦奥胡斯大学，2018年回国任职于基础所生物医学工程技术中心。前期主要致力于癌症靶向药物的研发，干细胞疾病模型的构建、以及生物材料在再生医学中的应用研究。目前主要从事中医药生物工程和再生医学以及中医药防治病毒基础性研。主持和参与欧洲地平线计划，欧盟第六、第七科技框架（玛丽居里行动），丹麦创新战略研究，国家重点研发战略性国际科技创新合作重点专项, 国自然青年项目、国自然面上项目等。研究成果先后发表在Nano Today, Journal of Controlled Release, ACS Applied Materials & Interfaces, Cellular Oncology 等国际权威杂志。
论文：
Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Promoted Wound Healing by Utilizing Coaxial PCL/Gelatin Nanofiber Membrane Int. J. Mol. Sci 2022/2/8
Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis Front. Bioeng. Biotechnol. 2022/1/24
Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining Front. Pharmacol. 2021/5/14
Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression Exp Mol Med 2009/10/1
A peptide antagonist of ErbB1 receptor inhibits receptor activation, tumor cell growth and migration in vitro and xenograft tumor growth in vivo Cellular Oncology 2010/1/1
Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells Curr Med Chem 2012/12/1
Identification of a novel antagonist of the ErbB1 receptor capable of inhibiting migration of human gliomablastoma cells Cell Oncology 2013/4/1
A peptide antagonist of ErbB receptors, Inherbin3, induces neurite outgrowth from rat cerebellar granule neurons through ErbB1 inhibition Neurochem Res 2013/10/1
Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay AAPS J 2014/2/1
Electrospun PCL/PEO coaxial fibers for basic fibroblast growth factor delivery J. Matter. Chem. B 2014/10/1
hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold Sci Rep 2015/2/1
Poly(norepinephrine) as a functional bio-interface for neuronal differentiation on electrospun fibers Phys Chem Chem Phys 2015/4/1
Effects of synthetic neural adhesion molecule mimetic peptides and related proteins on the cardiomyogenic differentiation of mouse embryonic stem cells Cell Physiol Biochem 2015/4/1
Three-dimenstional polydopamine functionalized coiled microfibrous scaffolds enhance human mesenchymal stem cells colonization and mild myofibroblastic differentiation ACS Appl Mater Interfaces 2016/1/1
Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation RSC Adv 2016/2/1
3D mechanical environment and chemical milieu influence hMSC fibrogenesis and fibroblast-to-myofibroblast transition RSC Adv 2017/1/1
Dual-delivery of FGF2/CTGF from silk fibroin/PLCL-PEO coaxial fibers enhance MSC proliferation and fibrogenesis Sci Rep 2017/8/1
Fibrogenic and angeiogenic commitments of hiPS-MSCs in CTGF-delivering scaffold in an immune-deficient mice model Journal of biomedical materials research PartB 2017/10/1
Visible light neural stimulation on graphitic-carbon nitride/graphene photocatalytic fibers ACS Appl Mater Interfaces 2017/10/1
Incorporation of bacteriophages in polycaprolactone/collagen fibers for antibacterial hemostatic dual-function J Biomed Mater Res B Appl Biomater 2018/10/1
MicroRNAs from plants to animals, do they define a new messenger for communication? Nutrition & Metabolism 2018/10/1
Tauroursodeoxycholic Acid (TUDCA) inhibits influenza A viral infection by disrupting vial proton channel M2 Science Bulletin 2019/2/1
Synchronous Delivery of Hydroxyapatite and Connective Tissue Growth Factor derived Osteoinductive Peptide Enhanced Osteogenesis Journal of Controlled Release 2019/3/1
Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System Front. Bioeng. Biotechnol. 2020/8/1
Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition Nanotechnology 2020/9/1
Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability Front. Chem. 2020/9/1
Peptide-based high-density lipoprotein promotes adipose tissue browning and restrains development of atherosclerosis and type 2 diabetes Nano Today 2020/12/18
专著：
获奖：
Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Promoted Wound Healing by Utilizing Coaxial PCL/Gelatin Nanofiber Membrane Int. J. Mol. Sci
Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis Front. Bioeng. Biotechnol.
Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining Front. Pharmacol.
Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression Exp Mol Med
A peptide antagonist of ErbB1 receptor inhibits receptor activation, tumor cell growth and migration in vitro and xenograft tumor growth in vivo Cellular Oncology
Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells Curr Med Chem
Identification of a novel antagonist of the ErbB1 receptor capable of inhibiting migration of human gliomablastoma cells Cell Oncology
A peptide antagonist of ErbB receptors, Inherbin3, induces neurite outgrowth from rat cerebellar granule neurons through ErbB1 inhibition Neurochem Res
Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay AAPS J
Electrospun PCL/PEO coaxial fibers for basic fibroblast growth factor delivery J. Matter. Chem. B
hiPS-MSCs differentiation towards fibroblasts on a 3D ECM mimicking scaffold Sci Rep
Poly(norepinephrine) as a functional bio-interface for neuronal differentiation on electrospun fibers Phys Chem Chem Phys
Effects of synthetic neural adhesion molecule mimetic peptides and related proteins on the cardiomyogenic differentiation of mouse embryonic stem cells Cell Physiol Biochem
Three-dimenstional polydopamine functionalized coiled microfibrous scaffolds enhance human mesenchymal stem cells colonization and mild myofibroblastic differentiation ACS Appl Mater Interfaces
Artificial extracellular matrix delivers TGFb1 regulating myofibroblast differentiation RSC Adv
3D mechanical environment and chemical milieu influence hMSC fibrogenesis and fibroblast-to-myofibroblast transition RSC Adv
Dual-delivery of FGF2/CTGF from silk fibroin/PLCL-PEO coaxial fibers enhance MSC proliferation and fibrogenesis Sci Rep
Fibrogenic and angeiogenic commitments of hiPS-MSCs in CTGF-delivering scaffold in an immune-deficient mice model Journal of biomedical materials research PartB
Visible light neural stimulation on graphitic-carbon nitride/graphene photocatalytic fibers ACS Appl Mater Interfaces
Incorporation of bacteriophages in polycaprolactone/collagen fibers for antibacterial hemostatic dual-function J Biomed Mater Res B Appl Biomater
MicroRNAs from plants to animals, do they define a new messenger for communication? Nutrition & Metabolism
Tauroursodeoxycholic Acid (TUDCA) inhibits influenza A viral infection by disrupting vial proton channel M2 Science Bulletin
Synchronous Delivery of Hydroxyapatite and Connective Tissue Growth Factor derived Osteoinductive Peptide Enhanced Osteogenesis Journal of Controlled Release
Construction of SARS-CoV-2 Virus-Like Particles by Mammalian Expression System Front. Bioeng. Biotechnol.
Paclitaxel-loaded lignin particle encapsulated into electrospun PVA/PVP composite nanofiber for effective cervical cancer cell inhibition Nanotechnology
Application of Functional Biocompatible Nanomaterials to Improve Curcumin Bioavailability Front. Chem.
Peptide-based high-density lipoprotein promotes adipose tissue browning and restrains development of atherosclerosis and type 2 diabetes Nano Today
