导师类型：博士生导师
单 位：07中医基础理论研究所
出生年月：1978年03月
专业职务：研究员
学 位：医学博士
毕业学校：北京中医药大学
第一学科：中西医结合
第二学科：中西医结合基础
研究方向：中医药防治代谢性疾病的基础研究
联系电话：64025179
邮 箱：zzgtcm@163.com
邮 编：100700
联系地址：北京市东城区东直门内南小街16号
个人简介： 张治国，男，1978年生，医学博士，博士后，研究员，博士研究生导师，日本长崎大学访学学者。主要从事中医药防治代谢性疾病的基础研究，致力于中医理论的科学内涵诠释。入选“全国中医药创新骨干人才”、“北京市东城区优秀人才”，荣获“中日笹川医学奖学金”。先后主持国家自然科学基金、北京市自然科学基金、中国博士后科学基金、北京市中医管理局、中国中医科学院等各级各类课题10余项，发表各类学术论文100余篇，其中SCI论文30余篇，主编参编著作4部，获得发明专利4项，实用新型专利3项。 学术兼职：国家科技专家库专家，国家自然科学基金通信评审专家，北京市自然科学基金评审专家，浙江省自然科学基金评审专家，陕西省自然科学基金评审专家，中国中西医结合学会理事，中华中医药学会中医基础理论分会委员。
论文：
Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway Aging-US 2019/9/3
A circRNA-miRNA-mRNA network plays a role in the protective effect of diosgenin on alveolar bone loss in ovariectomized rats BMC Complement Med Ther 2020/7/14
黄芪桂枝五物汤“无甘草”之探讨 中国中医基础医学杂志 2023/5/28
“水虚土乘”是更年期女性代谢综合征的核心病机 中国中医基础医学杂志 2023/4/28
Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression Front Cell Infect Microbiol 2023/3/27
Diosgenin reduces bone loss through the regulation of gut microbiota in ovariectomized rats Gene 2023/6/15
《伤寒杂病论》瘥后方方证探索 中国中医基础医学杂志 2021/11/30
Recent Advance in Regulatory Effect of GRP120 on Bone Metabolism Aging Dis 2023/2/1
Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1/PI3K/AKT signaling pathway J Ethnopharmacol 2023/1/1
Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking Comput Math Methods Med 2022/12/1
Dynamic Evolution of Cardiac Function and Glucose and Lipid Metabolism in Ovariectomized Rats and the Intervention Effect of Erxian Decoction Evid Based Complement Alternat Med 2022/12/1
Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS One 2022/11/1
Effect of Diosgenin on the Circulating MicroRNA Profile of Ovariectomized Rats Front Pharmacol 2020/3/6
从“方证相应”探讨黄连汤组成 中国实验方剂学杂志 2021/9/1
解读太阳病的分类 北京中医药大学学报 2021/7/30
“脾实”与“泻脾”探讨 中国中医基础医学杂志 2021/4/1
Monascin abrogates RANKL-mediated osteoclastogenesis in RAW264.7 cells via regulating MAPKs signaling pathway Front Pharmacol 2022/7/15
专利中药复方治疗骨质疏松症的用药规律分析 世界科学技术-中医药现代化 2021/9/1
《黄帝内经》“中气”理论的渊源与构建 中国中医基础医学杂志 2022/5/1
原发性骨质疏松症原义病机探讨 国际中医中药杂志 2022/5/1
Therapeutic effects of aqueous extract from Eclipta Herba on bone metabolism of ovariectomized rats Menopause 2013/2/1
High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio Int J Mol Sci 2014/9/1
The protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulating Wnt and p38 MAPK signaling Nutrients 2014/12/1
The effect of curcumin on aged Drosophila melanogaster: a pathway prediction analysis Chin J Integr Med 2015/2/1
Rhizoma Dioscoreae extract protects against alveolar bone loss in ovariectomized rats via microRNAs regulation Nutrients 2015/2/1
Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the protein-protein interaction network Mol Med Rep 2016/6/1
Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling Int J Mol Med 2017/5/1
Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats Nutrients 2017/10/1
Diosgenin protects against alveolar bone loss in ovariectomized rats via regulating lncRNAs Exp Ther Med 2018/9/3
The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model BMC Complement Altern Med 2018/9/3
专著：
沈绍功弟子验案精选 学苑出版社
中医全科门诊名医处方 化学工业出版社
《黄帝内经》“中气”概念及理论研究 学苑出版社
《方剂学》记忆手册 河南科学技术出版社
“肾齿相关”理论的科学内涵诠释 其他
获奖：
Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway Aging-US
A circRNA-miRNA-mRNA network plays a role in the protective effect of diosgenin on alveolar bone loss in ovariectomized rats BMC Complement Med Ther
黄芪桂枝五物汤“无甘草”之探讨 中国中医基础医学杂志
“水虚土乘”是更年期女性代谢综合征的核心病机 中国中医基础医学杂志
Alteration of the gut microbiome and correlated metabolism in a rat model of long-term depression Front Cell Infect Microbiol
Diosgenin reduces bone loss through the regulation of gut microbiota in ovariectomized rats Gene
《伤寒杂病论》瘥后方方证探索 中国中医基础医学杂志
Recent Advance in Regulatory Effect of GRP120 on Bone Metabolism Aging Dis
Er-Xian decoction attenuates ovariectomy-induced osteoporosis by modulating fatty acid metabolism and IGF1/PI3K/AKT signaling pathway J Ethnopharmacol
Exploring the Potential Mechanism of Artemisinin and Its Derivatives in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking Comput Math Methods Med
Dynamic Evolution of Cardiac Function and Glucose and Lipid Metabolism in Ovariectomized Rats and the Intervention Effect of Erxian Decoction Evid Based Complement Alternat Med
Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells PLoS One
Effect of Diosgenin on the Circulating MicroRNA Profile of Ovariectomized Rats Front Pharmacol
从“方证相应”探讨黄连汤组成 中国实验方剂学杂志
解读太阳病的分类 北京中医药大学学报
“脾实”与“泻脾”探讨 中国中医基础医学杂志
Monascin abrogates RANKL-mediated osteoclastogenesis in RAW264.7 cells via regulating MAPKs signaling pathway Front Pharmacol
专利中药复方治疗骨质疏松症的用药规律分析 世界科学技术-中医药现代化
《黄帝内经》“中气”理论的渊源与构建 中国中医基础医学杂志
原发性骨质疏松症原义病机探讨 国际中医中药杂志
Therapeutic effects of aqueous extract from Eclipta Herba on bone metabolism of ovariectomized rats Menopause
High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio Int J Mol Sci
The protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulating Wnt and p38 MAPK signaling Nutrients
The effect of curcumin on aged Drosophila melanogaster: a pathway prediction analysis Chin J Integr Med
Rhizoma Dioscoreae extract protects against alveolar bone loss in ovariectomized rats via microRNAs regulation Nutrients
Rhizoma Dioscoreae extract protects against alveolar bone loss by regulating the cell cycle: A predictive study based on the protein-protein interaction network Mol Med Rep
Protective effect of Rhizoma Dioscoreae extract against alveolar bone loss in ovariectomized rats via regulation of IL-6/STAT3 signaling Int J Mol Med
Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats Nutrients
Diosgenin protects against alveolar bone loss in ovariectomized rats via regulating lncRNAs Exp Ther Med
The protective effect of Er-Xian decoction against myocardial injury in menopausal rat model BMC Complement Altern Med
