郭娟


导师类型:博士生导师
单 位:12中药资源中心
出生年月:1983年03月
专业职务:研究员
学 位:理学博士
毕业学校:中国科学院武汉植物园
第一学科:中药学
第二学科:中药学
研究方向:分子生药学
联系电话:64087469
邮 箱:guojuanzy@163.com
邮 编:100700
联系地址:北京市东城区东直门内南小街16号
个人简介:郭娟,中国中医科学院,中药研究所,副研究员 科研与学术工作经历: 1.2013/12-至今,中国中医科学院,中药资源中心,副研究员 2.2013/05-2013.11,中国中医科学院,中药资源中心,助理研究员 3.2011/09-2011.11,中国科学院,上海植物生理生态研究所,访问学者 4.2010/04-2013.4,中国中医科学院,博士后,合作导师:黄璐琦 主持或参加科研项目(课题)及人才计划项目情况: 1.国家自然科学基金面上项目,81573532,P450s介导的丹参主要有效成分丹参酮五元呋喃环的生物合成研究,2016/01-2019/12,68.4万元,在研,主持 2.北京市东城区优秀人才培养资助项目,2015DZM-5,丹参酮生物合成途径解析,2015/05-2016/04,2万元,已结题,主持 3.国家自然科学基金青年科学基金项目,81403049,基于砖红色丹参突变株的丹参酮类化合物生物合成功能基因的挖掘,2015/01-2017/12,23万元,已结题,参加 4.国家自然科学基金青年科学基金项目,81202871,丹参酮类化合物结构修饰关键CYP450酶Miltiradiene-12-Hydroxylase的功能研究,2013/01-2015/12,23万元,已结题,主持 5.国家自然科学基金青年科学基金项目,81202872,基于丹参酮生物合成关键酶(GGPS1)的互作蛋白及其作用机理研究,2013/01-2015/12,23万元,已结题,参加 6.中国博士后科学基金,2012M510732,丹参酮生物合成途径P450基因的克隆和功能研究,2012-2014,5万元,主持 7.863计划,2012AA02A704,若干植物源化合物的人工合成体系构建,2012-2015,910万元,已结题,参加 8.国家自然科学基金青年科学基金项目,81001605,基于SAMe基因比较的金银花类药材质量评价方法的建立,2011/01-2013/12,20万元,已结题,参加 9.国家自然科学基金青年科学基金项目,30900076,中国淫羊藿属的分类学研究,2010/01-2012/12,19万元,已结题,参加
论文:
Cloning and functional analysis of two sterol-C24-methyltransferase 1 (SMT1) genes from Paris polyphylla Journal of Asian Natural Products Research 2017/1/15
Molecula r cloning and functional analysis of squalene synthase (SS) in Panax notoginseng. International Journal of Biological Macromolecules 2016/11/15
Functional Analysis of the Isopentenyl Diphosphate Isomerase of Salvia miltiorrhiza via Color Complementation and RNA Interference. Molecules 2015/5/15
Yeast synthetic biology for high-value metabolites FEMS Yeast Research 2015/1/15
Functional diversification of kaurene synthase-like genes in Isodon rubescens Plant Physiology 2017/5/15
Characterization of a monoterpene synthase from Paeonia lactiflora producing alpha-pinene as its single product Biotechnology Letters 2016/7/15
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones New Phytologist 2016/4/15
RNA interference targeting CYP76AH1 in hairy roots of Salvia miltiorrhiza reveals its key role in the biosynthetic pathway of tanshinones Biochemical and Biophysical Research Communications 2016/4/15
The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza Molecules 2015/9/15
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts PNAS 2013/7/15
专著:
Molecular Pharmacognosy Springer
The Salvia miltiorrhiza Genome Springer
丹参酮生物合成途径解析及其合成生物学研究 其他部级科研奖励(获奖证书上需盖有关部委“国徽章”)
获奖:
Cloning and functional analysis of two sterol-C24-methyltransferase 1 (SMT1) genes from Paris polyphylla Journal of Asian Natural Products Research
Molecula r cloning and functional analysis of squalene synthase (SS) in Panax notoginseng. International Journal of Biological Macromolecules
Functional Analysis of the Isopentenyl Diphosphate Isomerase of Salvia miltiorrhiza via Color Complementation and RNA Interference. Molecules
Yeast synthetic biology for high-value metabolites FEMS Yeast Research
Functional diversification of kaurene synthase-like genes in Isodon rubescens Plant Physiology
Characterization of a monoterpene synthase from Paeonia lactiflora producing alpha-pinene as its single product Biotechnology Letters
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones New Phytologist
RNA interference targeting CYP76AH1 in hairy roots of Salvia miltiorrhiza reveals its key role in the biosynthetic pathway of tanshinones Biochemical and Biophysical Research Communications
The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza Molecules
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts PNAS