导师类型：硕士生导师
单 位：05中药研究所
出生年月：1984年06月
专业职务：副研究员
学 位：理学博士
毕业学校：沈阳药科大学
第一学科：中药学
第二学科：中药学
研究方向：中药新剂型、中药经皮给药系统和中药药效物质基础研究
联系电话：18610351110
邮 箱：sshen@icmm.ac.cn
邮 编：100700
联系地址：北京市东直门内南小街16号
个人简介：沈硕，博士，中药学博士后，副研究员，硕士研究生导师。主要研究方向：中药新剂型、中药经皮给药系统和中药药效物质基础研究；在青蒿素类新型抗疟制剂及肿瘤靶向纳米制剂领域，进行了大量研究工作。先后主持或参与中国博士后科学基金、国家重大新药创制和国家自然科学基金等项目10余项。受知名制药企业或三甲医院委托，负责5项中药新药项目的研发；参与开发的中药外用改良型新药于2019年获得临床批件。近年来，相关研究成果在Journal of nanobiotechnology、Nanoscale、International journal of nanomedicine、中草药和药物分析杂志等国内外学术期刊发表论文40余篇，其中一作或通讯作者SCI论文10篇，单篇最高影响因子11.5 (5 year IF)。相关特色技术获得授权专利9项，其中国内发明专利6项，日本和新加坡等国际专利3项；参与编写著作5部，其中2部为副主编；获得省部级奖励1项。学术兼职：沈阳药科大学学报青年编委；中国中医药研究促进会中药制药专业委员会委员，世界中医药联合会经皮给药专业委员会会员。
论文：
Three New Chemical Constituents of Dryopteris crassirhizoma Nakai in Lianhua Qingwen Capsule and Investigation on Their Antiviral Potential Based on 3CL Hydrolase of SARS-CoV-2 Records of Natural Products 2023/6/8
Evaluations of the Chuanqi Ophthalmic Microemulsion In Situ Gel on Dry Age-Related Macular Degeneration Treatment Evidence-Based Complementary and Alternative Medicine 2020/8/19
Compound antimalarial ethosomal cataplasm: preparation, evaluation, and mechanism of penetration enhancement Internaitonal Journal of Nanomedicine 2015/6/30
Pharmacophore-Based Virtual Screening Toward the Discovery of Novel GLUT1 Inhibitors Journal of Computational Biophysics and Chemistry 2022/8/10
Computer-aided design of glucoside brain-targeted molecules based on 4PYP Journal of Molecular Graphics and Modelling 2020/12/21
Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy Journal of Nanobiotechnology 2022/8/13
Establishment and evaluation of glucose-modified nanocomposite liposomes for the treatment of cerebral malaria Journal of Nanobiotechnology 2022/7/6
Development of GLUT1-targeting alkyl glucoside-modified dihydroartemisinin liposomes for cancer therapy Nanoscale 2020/10/1
专著：
传统剂型的现代传承发展（丸、散、膏、丹、汤） 中国中医药出版社
获奖：
Three New Chemical Constituents of Dryopteris crassirhizoma Nakai in Lianhua Qingwen Capsule and Investigation on Their Antiviral Potential Based on 3CL Hydrolase of SARS-CoV-2 Records of Natural Products
Evaluations of the Chuanqi Ophthalmic Microemulsion In Situ Gel on Dry Age-Related Macular Degeneration Treatment Evidence-Based Complementary and Alternative Medicine
Compound antimalarial ethosomal cataplasm: preparation, evaluation, and mechanism of penetration enhancement Internaitonal Journal of Nanomedicine
Pharmacophore-Based Virtual Screening Toward the Discovery of Novel GLUT1 Inhibitors Journal of Computational Biophysics and Chemistry
Computer-aided design of glucoside brain-targeted molecules based on 4PYP Journal of Molecular Graphics and Modelling
Development of artesunate intelligent prodrug liposomes based on mitochondrial targeting strategy Journal of Nanobiotechnology
Establishment and evaluation of glucose-modified nanocomposite liposomes for the treatment of cerebral malaria Journal of Nanobiotechnology
Development of GLUT1-targeting alkyl glucoside-modified dihydroartemisinin liposomes for cancer therapy Nanoscale
